Clostridium botulinum is a spore-forming, gram-positive, anaerobic rod. A number of
different potent neurotoxins (from A–G) are produced by different strains. The name
is derived from the Latin for sausage, botulus, due to its association with food poisoning
from bad sausages. Botulinum toxin A is the most widely studied; it is the easiest
to obtain from culture and was the first to be commercially prepared as Botox (Allergan).
The toxin, consisting of two subunits (light and heavy chains are connected by a
disulphide bridge), selectively inhibits acetylcholine release at the neuromuscular
junctions in a dose-dependent manner.
different potent neurotoxins (from A–G) are produced by different strains. The name
is derived from the Latin for sausage, botulus, due to its association with food poisoning
from bad sausages. Botulinum toxin A is the most widely studied; it is the easiest
to obtain from culture and was the first to be commercially prepared as Botox (Allergan).
The toxin, consisting of two subunits (light and heavy chains are connected by a
disulphide bridge), selectively inhibits acetylcholine release at the neuromuscular
junctions in a dose-dependent manner.
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